The hosts proved too strong with the bat coming away with a seven-point DLS victory in the second T20I at Coolidge Cricket Ground.
The West Indies chose to strike first after winning the toss and Deandra Dottin (17) immediately got to work, slicing a four on her first ball from Diana Baig (1/31). Hayley Matthews (9) played well with a limit of her own as the pair headed for a 34-point opening position after four overs.
Just when the West Indies seemed comfortable, Pakistan hit their first wicket through Fatima Sana (2/18), who beat Dottin for 17 of her first delivery of the match. The visitors put the pressure on by taking the scalps of Matthews and Stafanie Taylor (5) in the next three overs.
The crucial West Indies partnership came in the form of Chedean Nation (28) and Kycia Knight (30 *), who combined 32 points. Nation started in 18th thanks to the second wicket of the Anam Amin match (2/31), then the West Indies reached 125/6 on their 20 overs.
Pakistan arrived in the crease and was immediately in conflict when Javeria Khan (0) was knocked out by Kyshona Knight with a direct hit on the fifth ball of the inning.
Iram Javed (15) provided a quick response to visitors before there were several saves in play.
In disturbing scenes, Chinelle Henry and Nation collapsed on the ground and were taken to hospital.
The covers were also drawn for the rain delays, which forced the contest to be decided by the DLS method.
Nida Dar was the pick for Pakistani hitters with 29 of 36 deliveries, including four limits.
The West Indies sealed the T20I series 2-0 with the third game to be played on Sunday at Sir Vivian Richards Stadium.